Nutramax Reference Line
FlexJoint Advanced
B
Evidence grade: B (80/100)
Weighted aggregate of each ingredient's strongest evidence (study quality × sample size). 4 ingredients.
Per-ingredient evidence
Glucosamine HCl
Strongest evidence: Randomized controlled trial, n=1,583
| Grade | n | Study | Finding |
|---|---|---|---|
| RCT | 1,583 | Glucosamine, Chondroitin, or the Two in Combination for Knee OA (GAIT)NEJM · 2026-01-12 | No significant overall pain reduction vs placebo; possible benefit in moderate-to-severe subgroup. |
| Cohort | 414 | Glucosamine sulfate use and delay of progression of knee OAArch Intern Med · 2026-01-12 | Long-term use associated with reduced joint-space narrowing over 3 years. |
Chondroitin Sulfate
Strongest evidence: Randomized controlled trial, n=604
| Grade | n | Study | Finding |
|---|---|---|---|
| RCT | 604 | Chondroitin sulfate vs celecoxib for knee OA (MOVES randomized trial)Ann Rheum Dis · 2026-01-12 | Non-inferior to celecoxib for pain and function over 6 months. |
MSM (Methylsulfonylmethane)
Strongest evidence: Case series / small trial, n=118
| Grade | n | Study | Finding |
|---|---|---|---|
| Case | 118 | MSM for osteoarthritis pain: a pilot clinical trialOsteoarthritis Cartilage · 2026-01-12 | Small improvement in pain and physical function vs placebo; pilot scale. |
Boswellia Serrata
Strongest evidence: Case series / small trial, n=75
| Grade | n | Study | Finding |
|---|---|---|---|
| Case | 75 | Boswellia extract in osteoarthritis of the kneePhytomedicine · 2026-03-18 | Reported pain/function improvement; short duration, small sample. |
Not medical advice. Grades reflect the quality and quantity of published evidence for an ingredient — not a health claim, endorsement, or guarantee of effect. An absent study is reported as insufficient, never as proof a thing does or does not work. Talk to a clinician before changing any regimen.